Heterogeneity of serum gelatinases MMP ‐2 and MMP ‐9 isoforms and charge variants

Heterogeneity of serum gelatinases MMP-2 and MMP-9 isoforms and charge variants

The matrix metalloproteinases (MMPs) gelatinase A (MMP-2) and gelatinase B (MMP-9) are mediators of brain injury in multiple sclerosis (MS) and valuable biomarkers of disease activity. We applied bidimensional zymography (2-DZ) as an extension of classic monodimensional zymography (1-DZ) to analyse the complete pattern of isoforms and post-translational modifications of both MMP-9 and MMP-2 pre...

Gelatinases MMP-9 and MMP-2 as indicators of airway inflammation in horses and calves

Role of gelatinases MMP-2 and MMP-9 in tissue remodeling following acute lung injury.

Acute lung injury is characterized by a severe disruption of alveolo-capillary structures and includes a variety of changes in lung cell populations. Evidence suggests the occurrence of rupture of the basement membranes and interstitial matrix remodeling during acute lung injury. The dynamic equilibrium of the extracellular matrix (ECM) under physiological conditions is a consequence of the bal...

The gelatinases MMP-2 and MMP-9 in Helicobacter pylori-induced gastritis

Investigation of MMP-2 and MMP-9 activities in canine sera with dilated cardiomyopathy

Dilated cardiomyopathy (DCM) is accompanied by myocytes and connective tissue changes. Matrix metalloproteinases (MMPs) play important roles in cardiac remodeling. It seems that the gelatinases (MMP-2 and MMP-9) are effective enzymes in cardiomyopathy. Dilated cardiomyopathy was confirmed in 22 dogs (patient group) including 11 female and 11 male by clinical examination, auscultation, thoracic ...